Pharmacological Properties of JTE-952, an Orally Available and Selective Colony Stimulating Factor 1 Receptor Kinase Inhibitor

Author:

Uesato Naofumi1,Miyagawa Naoki1,Inagaki Koji1,Kakefuda Reina1,Kitagawa Yoshihiro1,Matsuo Yushi1,Yamaguchi Takayuki1,Hata Takahiro1,Ikegashira Kazutaka1,Matsushita Mutsuyoshi1

Affiliation:

1. Central Pharmaceutical Research Institute, Japan Tobacco Inc.

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference32 articles.

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2. 2) Chapoval AI, Kamdar SJ, Kremlev SG, Evans R. CSF-1 (M-CSF) differentially sensitizes mononuclear phagocyte subpopulations to endotoxin in vivo: a potential pathway that regulates the severity of Gram-negative infections. J. Leukoc. Biol., 63, 245–252 (1998).

3. 3) Chitu V, Stanley ER. Colony-stimulating factor-1 in immunity and inflammation. Curr. Opin. Immunol., 18, 39–48 (2006).

4. 4) Hume DA, Pavli P, Donahue RE, Fidler IJ. The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo. J. Immunol., 141, 3405–3409 (1988).

5. 5) Dai XM, Ryan GR, Hapel AJ, Dominguez MG, Russell RG, Kapp S, Sylvestre V, Stanley ER. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood, 99, 111–120 (2002).

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