Risk Factors for Major Bleeding and Clinically Relevant Non-major Bleeding in Japanese Patients Treated with Edoxaban

Author:

Takase Tomoki1,Ikesue Hiroaki1,Nakagawa Haruna1,Kinoshita Megumi1,Muroi Nobuyuki1,Kitai Takeshi2,Furukawa Yutaka2,Hashida Tohru1

Affiliation:

1. Department of Pharmacy, Kobe City Medical Center General Hospital

2. Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference25 articles.

1. 1) Di Nisio M, Raskob G, Büller HR, Grosso MA, Zhang G, Winters SM, Cohen A. Prediction of major and clinically relevant bleeding in patients with VTE treated with edoxaban or vitamin K antagonists. Thromb. Haemost., 117, 784–793 (2017).

2. 2) Aisenberg J, Chatterjee-Murphy P, Friedman Flack K, Weitz JI, Ruff CT, Nordio F, Mercuri MF, Choi Y, Antman EM, Braunwald E, Giugliano RP. Gastrointestinal bleeding with edoxaban versus warfarin: results from the ENGAGE AF-TIMI 48 trial (effective anticoagulation with factor Xa next generation in atrial fibrillation-thrombolysis in myocardial infarction). Circ. Cardiovasc. Qual. Outcomes, 11, e003998 (2018).

3. 3) Zenati N, Gaboreau Y, Provencher CB, Albaladejo P, Bosson JL, Pernod G. Anaemia as an independent key risk factor for major haemorrhage in patients treated with vitamin K antagonists: Results of the SCORE prospective cohort. Thromb. Res., 151, 83–88 (2017).

4. 4) Ruíz-Giménez N, Suárez C, González R, Nieto JA, Todolí JA, Samperiz AL, Monreal M. Predictive variables for major bleeding events in patients presenting with documented acute venous thromboembolism. Findings from the RIETE registry. Thromb. Haemost., 100, 26–31 (2008).

5. 5) Westenbrink BD, Alings M, Granger CB, Alexander JH, Lopes RD, Hylek EM, Thomas L, Wojdyla DM, Hanna M, Keltai M, Steg PG, De Caterina R, Wallentin L, van Gilst WH. Anemia is associated with bleeding and mortality, but not stroke, in patients with atrial fibrillation: insights from the apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation (ARISTOTLE) trial. Am. Heart J., 185, 140–149 (2017).

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