Sophocarpine Inhibits Tumorgenesis of Colorectal Cancer via Downregulation of MEK/ERK/VEGF Pathway

Author:

Wang Qiaoling1,Wang Ting2,Zhu Lei3,He Nana1,Duan Chunyan1,Deng Wanli12,Zhang Hongping4,Zhang Xiaotian5

Affiliation:

1. Department of Oncology, Traditional Chinese Medical Hospital Affiliated Xinjiang Medical University

2. Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine

3. Department of Internal Medicine IV, Changji Traditional Chinese Medicine Hospital of Xinjiang

4. Department of Pharmacy, The Affiliated Hospital of Guangxin University of Chinese Medicine

5. Preventive Treatment of Disease Center, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference27 articles.

1. 1) Park YR, Seo SY, Kim SL, Zhu SM, Chun S, Oh JM, Lee MR, Kim SH, Kim IH, Lee SO, Lee ST, Kim SW. MicroRNA-206 suppresses PGE2-induced colorectal cancer cell proliferation, migration, and invasion by targeting TM4SF1. Biosci. Rep., 38, BSR20180664 (2018).

2. 2) Tan X, Zhang Z, Yao H, Shen L. Tim-4 promotes the growth of colorectal cancer by activating angiogenesis and recruiting tumor-associated macrophages via the PI3K/AKT/mTOR signaling pathway. Cancer Lett., 436, 119–128 (2018).

3. 3) Gupta GP, Massague J. Cancer metastasis: building a framework. Cell, 127, 679–695 (2006).

4. 4) Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G, Bettio M, Gavin A, Visser O, Bray F. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. Eur. J. Cancer, 103, 356–387 (2018).

5. 5) DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab., 7, 11–20 (2008).

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