Reconstituted Human Organ Models as a Translational Tool for Human Organ Response: Definition, Expectations, Cases, and Strategies for Implementation in Drug Discovery and Development

Author:

Tetsuka Kazuhiro1,Ohbuchi Masato1,Kawabe Tetsuhiro1,Goto Takayuki1,Kiyonaga Fumiko1,Takama Kaori1,Yamazaki Shunji1,Fujimori Akira1

Affiliation:

1. Astellas Pharma Inc.

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference57 articles.

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2. 2) Method of the Year 2017: Organoids. Nat. Methods, 15, 1 (2018).

3. 3) Junaid A, Mashaghi A, Hankemeier T, Vulto P. An end-user perspective on organ-on-a-chip: assays and usability aspects. Curr. Opin. Biomed. Eng., 1, 15–22 (2017).

4. 4) Ishida S. Organs-on-a-chip: current applications and consideration points for in vitro ADME-Tox studies. Drug Metab. Pharmacokinet., 33, 49–54 (2018).

5. 5) Kanamori T, Sugiura S, Sakai Y. Technical aspects of microphysiological systems (MPS) as a promising wet human-in-vivo simulator. Drug Metab. Pharmacokinet., 33, 40–42 (2018).

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