Effect of Obesity on Hematotoxicity Induced by Carboplatin and Paclitaxel Combination Therapy in Patients with Gynecological Cancer

Author:

Ando Yosuke1,Hayashi Takahiro12,Shiouchi Hideyo2,Tanaka Chihiro2,Ito Kaori3,Nishibe Seira1,Miyata Nanaho1,Horiba Ruri1,Yanagi Hisano4,Fujii Takuma5,Kawada Kenji4,Ikeda Yoshiaki2,Yamada Shigeki1

Affiliation:

1. Department of Clinical Pharmacy, Fujita Health University School of Medicine

2. College of Pharmacy, Kinjo Gakuin University

3. Department of Hematology, Fujita Health University School of Medicine

4. Department of Medical Oncology, Fujita Health University School of Medicine

5. Department of Obstetrics and Gynecology, Fujita Health University School of Medicine

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference29 articles.

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2. 2) du Bois A, Lück HJ, Meier W, Adams HP, Möbus V, Costa S, Bauknecht T, Richter B, Warm M, Schröder W, Olbricht S, Nitz U, Jackisch C, Emons G, Wagner U, Kuhn W, Pfisterer J. A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. J. Natl. Cancer Inst., 95, 1320–1329 (2003).

3. 3) Kitagawa R, Katsumata N, Shibata T, Kamura T, Kasamatsu T, Nakanishi T, Nishimura S, Ushijima K, Takano M, Satoh T, Yoshikawa H. Paclitaxel plus carboplatin versus paclitaxel plus cisplatin in metastatic or recurrent cervical cancer: The open-label randomized phase III trial JCOG0505. J. Clin. Oncol., 33, 2129–2135 (2015).

4. 4) Nomura H, Aoki D, Michimae H, Mizuno M, Nakai H, Arai M, Sasagawa M, Ushijima K, Sugiyama T, Saito M, Tokunaga H, Matoda M, Nakanishi T, Watanabe Y, Takahashi F, Saito T, Yaegashi N. Effect of taxane plus platinum regimens vs. doxorubicin plus cisplatin as adjuvant chemotherapy for endometrial cancer at a high risk of progression: A randomized clinical trial. JAMA Oncol., 5, 833–840 (2019).

5. 5) Egorin MJ, Van Echo DA, Tipping SJ, Olman EA, Whitacre MY, Thompson BW, Aisner J. Pharmacokinetics and dosage reduction of cis-diammine (1,1-cyclobutanecarboxylato) platinum in patients with impaired renal function. Cancer Res., 44, 5432–5438 (1984).

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