Unique Genotyping Protocol of CYP2D6 Allele Frequency Using Real Time Quantitative PCR from Japanese Healthy Women

Author:

Kisoi Madoka1,Imai Miho1,Yamamura Miwako1,Sakaguchi Yui1,Murata Shigenori12,Ichikawa Atsushi23,Kinoshita Kenji123

Affiliation:

1. School of Pharmaceutical Sciences, Mukogawa Women’s University

2. Institute of Biosciences, Mukogawa Women’s University

3. Bio Education Laboratory

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference29 articles.

1. 1) Eichelbaum M, Ingelman-Sundberg M, Evans WE. Pharmacogenomics and individualized drug therapy. Annu. Rev. Med., 57, 119–137 (2006).

2. 2) Laika B, Leucht S, Heres S, Steimer W. Intermediate metabolizer: increased side effects in psychoactive drug therapy. The key to cost-effectiveness of pretreatment CYP2D6 screening? Pharmacogenomics J., 9, 395–403 (2009).

3. 3) Ingelman-Sundberg M. Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J., 5, 6–13 (2005).

4. 4) Sim SC, Ingelman-Sundberg M. The Human Cytochrome P450 (CYP) Allele Nomenclature website: a peer-reviewed database of CYP variants and their associated effects. Hum. Genomics, 4, 278–281 (2010).

5. 5) Ingelman-Sundberg M, Sim SC, Gomez A, Rodriguez-Antona C. Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol. Ther., 116, 496–526 (2007).

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