Ethenzamide Exerts Analgesic Effect at the Spinal Cord via Multiple Mechanisms of Action Including the 5HT2B Receptor Blockade in the Rat Formalin Test

Author:

Nikaido Takato1,Maruyama Chikashi1,Hamanaka Minako1,Yamaguchi Chiharu1,Fujimaru Yukiko1,Nakanishi Yutaka2,Asano Toshiki1,Takaoka Akiko1

Affiliation:

1. Self-medication R&D laboratories, Taisho Pharmaceutical Co., Ltd.

2. Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd.

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference37 articles.

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2. 2) Okuyama S, Tachikawa S, Aihara H, Kameyama T. Studies on the combined analgesic effect of ibuprofen and antipyretic analgesic drugs. Jpn. Pharmacol. Ther., 18, 3359–3603 (1990).

3. 3) Matsui T. Effects of ethenzamide on spinal reflex potentials in cats. Jap. J. Oral Biol., 20, 581–590 (1978).

4. 4) Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain, 152 (Suppl.), S2–S15 (2011).

5. 5) Hylden JL, Nahin RL, Traub RJ, Dubner R. Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: the contribution of dorsal horn mechanisms. Pain, 37, 229–243 (1989).

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