Helicid Ameliorates Learning and Cognitive Ability and Activities cAMP/PKA/CREB Signaling in Chronic Unpredictable Mild Stress Rats

Author:

Li Xu-Yi1,Qi Wei-Wei2,Zhang Yuan-Xiang1,Jiang Si-Yan1,Yang Bin3,Xiong Lei1,Tong Jiu-Cui13

Affiliation:

1. Wannan Medical College

2. Department of Pharmacy, Second Affiliated Hospital of Wannan Medical College

3. Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference35 articles.

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2. 2) Lang UE, Borgwardt S. Molecular mechanisms of depression: perspectives on new treatment strategies. Cell. Physiol. Biochem., 31, 761–777 (2013).

3. 3) Maes M, Leonard BE, Myint AM, Kubera M, Verkerk R. The new ‘5-HT’ hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry, 35, 702–721 (2011).

4. 4) Starr KR, Price GW, Watson JM, Atkinson PJ, Arban R, Melotto S, Dawson LA, Hagan JJ, Upton N, Duxon MS. SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test. Neuropsychopharmacology, 32, 2163–2172 (2007).

5. 5) Didier S, Sauvé F, Domise M, Buée L, Marinangeli C, Vingtdeux V. AMP-activated protein kinase controls immediate early genes expression following synaptic activation through the PKA/CREB pathway. Int. J. Mol. Sci., 19, 3716 (2018).

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