Investigating DNA Methylation of SHATI/NAT8L Promoter Sites in Blood of Unmedicated Patients with Major Depressive Disorder

Author:

Miyanishi Hajime1,Uno Kyosuke12,Iwata Mina1,Kikuchi Yuu3,Yamamori Hidenaga3,Yasuda Yuka3,Ohi Kazutaka3,Hashimoto Ryota34,Hattori Kotaro5,Yoshida Sumiko5,Goto Yu-ichi6,Sumiyoshi Tomiki6,Nitta Atsumi1

Affiliation:

1. Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, University of Toyama

2. Laboratory of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University

3. Department of Psychiatry, Osaka University Graduate School of Medicine

4. Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry

5. Medical Genome Center, National Center of Neurology and Psychiatry

6. Department of Preventive Intervention, National Institute of Mental Health, National Center of Neurology and Psychiatry

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference39 articles.

1. 1) Trivedi MH, Rush AJ, Wisniewski SR, Nierenberg AA, Warden D, Ritz L, Norquist G, Howland RH, Lebowitz B, McGrath PJ, Shores-Wilson K, Biggs MM, Balasubramani GK, Fava M. Evaluation of outcomes with citalopram for MDD using measurement-based care in STAR*D: implications for clinical practice. Am. J. Psychiatry, 163, 28–40 (2006).

2. 2) Jiang C, Lin WJ, Sadahiro M, Labonté B, Menard C, Pfau ML, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR. VGF function in MDD and antidepressant efficacy. Mol. Psychiatry, 23, 1632–1642 (2018).

3. 3) Keller MB, Gelenberg AJ, Hirschfeld RM, Rush AJ, Thase ME, Kocsis JH, Markowitz JC, Fawcett JA, Koran LM, Klein DN, Russell JM, Kornstein SG, McCullough JP, Davis SM, Harrison WM. The treatment of chronic MDD, part 2: a double-blind, randomized trial of sertraline and imipramine. J. Clin. Psychiatry, 59, 598–607 (1998).

4. 4) Keller MB, McCullough JP, Klein DN, Arnow B, Dunner DL, Gelenberg AJ, Markowitz JC, Nemeroff CB, Russell JM, Thase ME, Trivedi MH, Zajecka J. A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic MDD. N. Engl. J. Med., 342, 1462–1470 (2000).

5. 5) Kaufman J, Gelernter J, Hudziak JJ, Tyrka AR, Coplan JD. The Research Domain Criteria (RDoC) project and studies of risk and resilience in maltreated children. J. Am. Acad. Child Adolesc. Psychiatry, 54, 617–625 (2015).

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