Supplemented Chondroitin Sulfate and Hyaluronic Acid Suppress Mineralization of the Chondrogenic Cell Line, ATDC5, via Direct Inhibition of Alkaline Phosphatase

Author:

Kudo Toshiya1,Nakatani Sachie1,Kakizaki Misato1,Arai Ai1,Ishida Keisuke1,Wada Masahiro1,Kobata Kenji1

Affiliation:

1. Department of Pharmaceutical Sciences, Josai University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference40 articles.

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2. 2) Watanabe H, Yamada Y, Kimata K. Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function. J. Biochem., 124, 687–693 (1998).

3. 3) Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int. J. Biochem. Cell Biol., 40, 46–62 (2008).

4. 4) Adams CS, Shapiro IM. The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis. Crit. Rev. Oral Biol. Med., 13, 465–473 (2002).

5. 5) Drissi H, Zuscik M, Rosier R, O’Keefe R. Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis. Mol. Aspects Med., 26, 169–179 (2005).

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