Alterations in Cisplatin Pharmacokinetics and Its Acute/Sub-chronic Kidney Injury over Multiple Cycles of Cisplatin Treatment in Rats

Author:

Okada Akira1,Fukushima Keizo1,Fujita Mai1,Nakanishi Mana1,Hamori Mami2,Nishimura Asako2,Shibata Nobuhito2,Sugioka Nobuyuki1

Affiliation:

1. Department of Clinical Pharmacokinetics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

2. Department of Biopharmaceutics, Faculty of Pharmaceutical Science, Doshisha Women’s College of Liberal Arts

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference31 articles.

1. 1) Faig J, Haughton M, Taylor RC, D’Agostino RB Jr, Whelen MJ, Porosnicu Rodriguez KA, Bonomi M, Murea M, Porosnicu M. Retrospective analysis of cisplatin nephrotoxicity in patients with head and neck cancer receiving outpatient treatment with concurrent high-dose cisplatin and radiotherapy. Am. J. Clin. Oncol., 2016, 1 (2016).

2. 2) Latcha S, Jaimes EA, Patil S, Glezerman IG, Mehta S, Flombaum CD. Long-term renal outcomes after cisplatin treatment. Clin. J. Am. Soc. Nephrol., 11, 1173–1179 (2016).

3. 3) Cole WC, Wolf W. Preparation and metabolism of a cisplatin/serum protein complex. Chem. Biol. Interact., 30, 223–235 (1980).

4. 4) Hanada K, Ninomiya K, Ogata H. Pharmacokinetics and toxicodynamics of cisplatin and its metabolites in rats: relationship between renal handling and nephrotoxicity of cisplatin. J. Pharm. Pharmacol., 52, 1345–1353 (2000).

5. 5) Filipski KK, Mathijssen RH, Mikkelsen TS, Schinkel AH, Sparreboom A. Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity. Clin. Pharmacol. Ther., 86, 396–402 (2009).

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