Syntheses of (4,1-Benzoxazepine-3-ylidene)acetic Acid Derivatives and Their Inhibition of Squalene Synthase.-Reference-Cited by-同舟云学术

Syntheses of (4,1-Benzoxazepine-3-ylidene)acetic Acid Derivatives and Their Inhibition of Squalene Synthase.

Published:2002 Issue:1 Volume:50 Page:53-58
ISSN:0009-2363
Container-title:Chemical and Pharmaceutical Bulletin
language:en
Short-container-title:CHEMICAL & PHARMACEUTICAL BULLETIN

Author:

Miki Takashi¹,Kori Masakuni¹,Tozawa Ryu-ichi¹,Nakamura Masahira¹,Sugiyama Yasuo¹,Yukimasa Hidefumi¹

Affiliation:

1. Takeda Chemical Industries, Ltd., Pharmaceutical Research Division

Publisher

Pharmaceutical Society of Japan

Subject

Drug Discovery,General Chemistry,General Medicine

Link

http://www.jstage.jst.go.jp/article/cpb/50/1/50_1_53/_pdf

Reference11 articles.

1. 1) Part 3 in the series of studies on 4,1-benzoxazepine derivatives as squalene synthase inhibitors: a) Part 1: Miki T., Kori M., Fujishima A., Mabuchi H., Tozawa R., Nakamura M., Sugiyama Y., Yukimasa H., Bioorg. Med. Chem., 10, 385—400 (2002); b) Part 2: Miki T., Kori M., Mabuchi H., Banno H., Tozawa R., Nakamura M., Itokawa S., Sugiyama Y., Yukimasa H., ibid., 10, 401—414 (2002).

2. 2) Yukimasa H., Kori M., Tozawa R., Sigiyama Y. (Takeda), Eur. Patent, 645377 (1995) [Chem. Abstr., 123, 256777w (1995)].

3. Efficient synthetic method for ethyl (+)-(2S,3S)-3-((S)-3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxiranecarboxylate (EST), a new inhibitor of cysteine proteinases.

4. 4) Reaction of 5a with 4-nitrophenyl ester³⁾ of dl-trans-epoxysuccinic acid monoethyl ester did not proceed.

5. Regio- and Stereoseloctive Intramolecular Epoxide Cyclizations.

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1. Stereoselective Synthesis of Functionalized Benzooxazepino[5,4-a]isoindolone Derivatives via Cesium Carbonate Catalyzed Formal [5 + 2] Annulation of 2-(2-Hydroxyphenyl)isoindoline-1,3-dione with Allenoates;Organic Letters;2018-04-04

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