Evidence of Different Pharmacokinetics Including Relationship among AUC, Peak, and Trough Levels between Cyclosporine and Tacrolimus in Renal Transplant Recipients Using New Pharmacokinetic Parameter—Why Cyclosporine Is Monitored by C2 Level and Tacrolimus by Trough Level

Evidence of Different Pharmacokinetics Including Relationship among AUC, Peak, and Trough Levels between Cyclosporine and Tacrolimus in Renal Transplant Recipients Using New Pharmacokinetic Parameter—Why Cyclosporine Is Monitored by C₂ Level and Tacrolimus by Trough Level—

Published:2008 Issue:1 Volume:31 Page:90-94
ISSN:0918-6158
Container-title:Biological & Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Takeuchi Hironori¹,Matsuno Naoto²,Senuma Kayoko¹,Hirano Toshihiko³,Yokoyama Takayoshi²,Taira Shinichiro²,Kihara Yu²,Kuzuoka Kentaro²,Konno Osamu²,Jojima Yoshimaro²,Mejit Abudushukur²,Akashi Isao²,Nakamura Yuki²,Iwamoto Hitoshi²,Hama Koichiro²,Iwahori Tohru²,Ashizawa Tatsuto²,Nagao Takeshi²,Toraishi Tatsunori⁴,Okuyama Kiyoshi⁴,Oka Kitaro³,Unezaki Sakae¹

Affiliation:

1. Department of Practical Pharmacy, Tokyo University of Pharmacy and Life Sciences

2. Department of Fifth Surgery, Hachioji Medical Center, Tokyo Medical University

3. Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Sciences

4. Department of Pharmaceutics, Hachioji Medical Center, Tokyo Medical University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/31/1/31_1_90/_pdf

Reference11 articles.

1. 1) Wang C. H., Ko W. J., Chou N. K., Wang S. S., Transplant Proc., 36, 2386—2387 (2004).

2. 2) Grevel J., Welsh M. S., Kahan B., Ther. Drug Monit., 11, 246—248 (1989).

3. 3) Meyer M. M., Munar M., Udeaja J., Bennett W., J. Am. Soc. Nephrol., 4, 1306—1315 (1993).

4. 4) Lindholm A., Kahan B. D., Clin. Pharmacol. Ther., 54, 205—217 (1993).

5. 6) Levy G. A., BioDrugs, 15, 279—290 (2001).

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