Changes in the Enzymatic Properties of CYP2D6 by the Substitution of Phenylalanine at Position 120 by Alanine-Reference-Cited by-同舟云学术

Changes in the Enzymatic Properties of CYP2D6 by the Substitution of Phenylalanine at Position 120 by Alanine

Published:2004 Issue:5 Volume:50 Page:503-510
ISSN:1344-9702
Container-title:Journal of Health Science
language:en
Short-container-title:JOURNAL OF HEALTH SCIENCE

Author:

Masuda Kazufumi¹,Hashimoto Hiroki¹,Tamagake Keietsu¹,Okuda Yukie²,Tsuzuki Daisuke²,Isobe Takashi²,Hichiya Hiroyuki²,Hanioka Nobumitsu²,Yamamoto Shigeo³,Narimatsu Shizuo²

Affiliation:

1. Laboratory of Pharmaceutical Physical Chemistry, Faculty of Pharmaceutical Sciences, Okayama University

2. Laboratory of Health Chemistry, Faculty of Pharmaceutical Sciences, Okayama University

3. Laboratory of Biomolecular Sciences, Faculty of Pharmaceutical Sciences, Okayama University

Publisher

Pharmaceutical Society of Japan

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://www.jstage.jst.go.jp/article/jhs/50/5/50_5_503/_pdf

Reference21 articles.

1. Cytochromes P450 and metabolism of xenobiotics

2. Summary of information on human CYP enzymes: human P450 metabolism data

3. Bioinformatics Research on Inter-racial Difference in Drug Metabolism I. Analysis on Frequencies of Mutant Alleles and Poor Metabolizers on CYP2D6 and CYP2C19

4. Stereoselectivity in Bunitrolol 4-Hydroxylation in Liver Microsomes from Marmosets and Japanese Monkeys.

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