Effectiveness and Safety of Antiemetic Aprepitant in Japanese Patients Receiving High-Dose Chemotherapy Prior to Autologous Hematopoietic Stem Cell Transplantation

Author:

Uchida Mayako1,Ikesue Hiroaki1,Miyamoto Toshihiro2,Kato Koji2,Suetsugu Kimitaka1,Ichinose Kimiko3,Hiraiwa Hiromi3,Sakurai Asako3,Takenaka Katsuto2,Muta Tsuyoshi2,Iwasaki Hiromi4,Teshima Takanori4,Shiratsuchi Motoaki5,Egashira Nobuaki1,Akashi Koichi2,Oishi Ryozo1

Affiliation:

1. Department of Pharmacy, Kyushu University Hospital

2. Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences

3. Unit for Cell Therapy and Transplantation, Kyushu University Hospital

4. Center for Cellular and Molecular Medicine, Kyushu University Hospital

5. Department of Medicine and Bioregulatory Science, Kyushu University Graduate School of Medical Sciences

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference30 articles.

1. 1) Hesketh PJ. Chemotherapy-induced nausea and vomiting. N. Engl. J. Med., 358, 2482–2494 (2008).

2. 2) Roila F, Herrstedt J, Aapro M, Gralla RJ, Einhorn LH, Ballatori E, Bria E, Clark-Snow RA, Espersen BT, Feyer P, Grunberg SM, Hesketh PJ, Jordan K, Kris MG, Maranzano E, Molassiotis A, Morrow G, Olver I, Rapoport BL, Rittenberg C, Saito M, Tonato M, Warr D, ESMO/MASCC Guidelines Working Group. Guideline update for MASCC and ESMO in the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting: results of the Perugia consensus conference. Ann. Oncol., 21 (Suppl. 5), v232–v243 (2010).

3. 3) National Comprehensive Cancer Network (NCCN). “NCCN Clinical Practice Guidelines in Oncology. Antiemesis. V.1.2012.”: ‹http://www.nccn.org/professionals/physician_gls/pdf/antiemesis.pdf›, cited 9 October, 2012.

4. 4) Einhorn LH, Grunberg SM, Rapoport B, Rittenberg C, Feyer P. Antiemetic therapy for multiple-day chemotherapy and additional topics consisting of rescue antiemetics and high-dose chemotherapy with stem cell transplant: review and consensus statement. Support. Care Cancer, 19 (Suppl. 1), S1–S4 (2011).

5. 5) Abbott B, Ippoliti C, Hecth D, Bruton J, Whaley B, Champlin R. Granisetron (Kytril) plus dexamethasone for antiemetic control in bone marrow transplant patients receiving highly emetogenic chemotherapy with or without total body irradiation. Bone Marrow Transplant., 25, 1279–1283 (2000).

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