Single- and Multiple-Dose Pharmacokinetics of a Novel Tetramethylpyrazine Reservoir-Type Transdermal Patch versus Tetramethylpyrazine Phosphate Oral Tablets in Healthy Normal Volunteers, and in Vitro/in Vivo Correlation-Reference-Cited by-同舟云学术

Single- and Multiple-Dose Pharmacokinetics of a Novel Tetramethylpyrazine Reservoir-Type Transdermal Patch versus Tetramethylpyrazine Phosphate Oral Tablets in Healthy Normal Volunteers, and in Vitro/in Vivo Correlation

Published:2013 Issue:6 Volume:36 Page:931-937
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Shen Teng¹,Xu Huinan¹,Weng Weiyu²,Zhang Jianfang¹

Affiliation:

1. Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University

2. School of Pharmacy, East China University of Science and Technology

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/36/6/36_b12-00909/_pdf

Reference33 articles.

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2. Pharmacokinetics of tetramethylpyrazine in rat blood and brain using microdialysis

3. 3) Hintz KK, Ren J. Tetramethylpyrazine elicits disparate responses in cardiac contraction and intracellular Ca²⁺ transients in isolated adult rat ventricular myocytes. Vascul. Pharmacol., 40, 213–217 (2003).

4. 4) Li M, Handa S, Ikeda Y, Goto S. Specific inhibiting characteristics of tetramethylpyrazine, one of the active ingredients of the Chinese herbal medicine ‘Chuanxiong,’ on platelet thrombus formation under high shear rates. Thromb. Res., 104, 15–28 (2001).

5. 5) Sheu JR, Kan YC, Hung WC, Ko WC, Yen MH. Mechanisms involved in the antiplatelet activity of tetramethylpyrazine in human platelets. Thromb. Res., 88, 259–270 (1997).

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