Baicalein 6-O-β-d-Glucopyranuronoside Is a Main Metabolite in the Plasma after Oral Administration of Baicalin, a Flavone Glucuronide of Scutellariae Radix, to Rats

Author:

Akao Teruaki1,Sato Keisuke1,He Ju-Xiu1,Ma Chao-Mei2,Hattori Masao2

Affiliation:

1. Graduate School of Medicine and Pharmaceutical Sciences

2. Institute of Natural Medicine, University of Toyama

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference20 articles.

1. 1) Koda A, Nagai H, Wada H. Pharmacological actions of baicalin and baicalein. 2. On active anaphylaxis. Nippon Yakurigaku Zasshi, 66, 194–213 (1970).

2. 2) Kubo M, Matsuda H, Tanaka M, Kimura Y, Okuda H, Higashino M, Tani T, Namba K, Arichi S. Studies on Scutellariae Radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellariae Radix. Chem. Pharm. Bull., 32, 2724–2729 (1984).

3. 3) Baylor NW, Fu T, Yan YD, Ruscetti FW. Inhibition of human T cell leukemia virus by the plant flavonoid baicalin (7-glucuronic acid, 5,6-dihydroxyflavone). J. Infect. Dis., 165, 433–437 (1992).

4. 4) Li BQ, Fu T, Dongyan Y, Mikovits JA, Ruscetti FW, Wang JM. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem. Biophys. Res. Commun., 276, 534–538 (2000).

5. 5) Inoue T, Jackson EK. Strong antiproliferative effects of baicalein in cultured rat hepatic stellate cells. Eur. J. Pharmacol., 378, 129–135 (1999).

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