Decrease in Venous Irritation by Adjusting the Concentration of Injected Bendamustine

Author:

Watanabe Hiroyuki1,Ikesue Hiroaki1,Tsujikawa Tomoko1,Nagata Kenichiro1,Uchida Mayako1,Suetsugu Kimitaka1,Egashira Nobuaki1,Muta Tsuyoshi2,Kato Koji2,Takenaka Katsuto2,Ohga Saiji3,Matsushima Takamitsu4,Shiratsuchi Motoaki4,Miyamoto Toshihiro2,Teshima Takanori5,Akashi Koichi2,Oishi Ryozo1

Affiliation:

1. Department of Pharmacy, Kyushu University Hospital

2. Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences

3. Department of Clinical Radiology, Kyushu University Graduate School of Medical Sciences

4. Department of Medicine and Bioregulatory Science, Kyushu University Graduate School of Medical Sciences

5. Center for Cellular and Molecular Medicine, Kyushu University Hospital

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference18 articles.

1. 1) Strumberg D, Harstrick A, Doll K, Hoffmann B, Seeber S. Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines. Anticancer Drugs, 7, 415–421 (1996).

2. 2) Leoni LM, Bailey B, Reifert J, Bendall HH, Zeller RW, Corbeil J, Elliott G, Niemeyer CC. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin. Cancer Res., 14, 309–317 (2008).

3. 3) Weidmann E, Kim SZ, Rost A, Schuppert H, Seipelt G, Hoelzer D, Mitrou PS. Bendamustine is effective in relapsed or refractory aggressive non-Hodgkin’s lymphoma. Ann. Oncol., 13, 1285–1289 (2002).

4. 4) Rummel MJ, Al-Batran SE, Kim SZ, Welslau M, Hecker R, Kofahl-Krause D, Josten KM, Dürk H, Rost A, Neise M, von Grünhagen U, Chow KU, Hansmann ML, Hoelzer D, Mitrou PS. Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin’s lymphoma. J. Clin. Oncol., 23, 3383–3389 (2005).

5. Phase I and pharmacokinetic study of bendamustine hydrochloride in relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma

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