Mast Cell Stabilizing Effect of (−)-Elema-1,3,11(13)-trien-12-ol and Thujopsene from Thujopsis dolabrata Is Mediated by Down-Regulation of Interleukin-4 Secretion in Antigen-Induced RBL-2H3 Cells

Author:

Kim Chul-Hee1,Lee Taehun1,Oh Ikhoon1,Nam Kung-Woo2,Kim Kyeong Ho3,Oh Ki-Bong4,Shin Jongheon1,Mar Woongchon1

Affiliation:

1. Natural Products Research Institute, College of Pharmacy, Seoul National University

2. Office of Industrial Cooperation, Soon Chun Hyang University

3. College of Pharmacy, Kangwon National University

4. School of Agriculture Biotechnology, Seoul National University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference49 articles.

1. 1) Etzel RA. How environmental exposures influence the development and exacerbation of asthma. Pediatrics, 112, 233–239 (2003).

2. 2) Bornehag CG, Sundell J, Weschler CJ, Sigsgaard T, Lundgren B, Hasselgren M, Hägerhed-Engman L. The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Environ. Health Perspect., 112, 1393–1397 (2004).

3. 3) Rönmark E, Bjerg A, Perzanowski M, Platts-Mills T, Lundbäck B. Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden. J. Allergy Clin. Immunol., 124, 357–363, 363, e351–e315 (2009).

4. 4) Beasley R, Crane J, Lai CK, Pearce N. Prevalence and etiology of asthma. J. Allergy Clin. Immunol., 105, S466–S472 (2000).

5. 5) Cookson W, Moffatt M. Making sense of asthma genes. N. Engl. J. Med., 351, 1794–1796 (2004).

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