Method for Individualized Evaluation of Antiemetic Effect Induced by 5-HT3 Receptor Antagonist

Author:

Nakamura Hironori1,Yokoyama Haruko1,Yoshimoto Koichi2,Nakajima Akihiro3,Okuyama Kiyoshi2,Iwase Osamu3,Yamada Yasuhiko1

Affiliation:

1. Department of Clinical Evaluation of Drug Efficacy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

2. Department of Pharmacy, Tokyo Medical University Hachioji Medical Center

3. Department of Hematology, Tokyo Medical University Hachioji Medical Center

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference17 articles.

1. 1) Andrews PL, Rapeport WG, Sanger GJ. Neuropharmacology of emesis induced by anti-cancer therapy. Trends Pharmacol. Sci., 9, 334–341 (1988).

2. 2) Cubeddu LX, Hoffmann IS, Fuenmayor NT, Finn AL. Efficacy of ondansetron (GR 38032F) and the role of serotonin in cisplatin-induced nausea and vomiting. N. Engl. J. Med., 322, 810–816 (1990).

3. 3) Kumakura H, Koyanagi J, Nishioka Y, Sato M, Nakajima T, Nakahira K, Tateno M. Phase I Study of Granisetron (Second Report)—Pharmacokinetics of Granisetron following Single and Repeat Intravenous Drip Infusion in Japanese Healthy Volinteers—. Rinsho Iyaku, 6 (Suppl. 5), 25–34 (1990).

4. 4) Carmichael J, Cantwell BM, Edwards CM, Zussman BD, Thompson S, Rapeport WG, Harris AL. A pharmacokinetic study of granisetron (BRL 43694A), a selective 5-HT3 receptor antagonist: correlation with anti-emetic response. Cancer Chemother. Pharmacol., 24, 45–49 (1989).

5. Clinical Evaluation of Antiemetic Effects of 5-hydroxytryptamine Receptor type 3 (5HT3 Receptor) Antagonists Based on Changes in Eating Condition in Cancer Patients Receiving Chemotherapy

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