Identification of the Risk Factors Associated with Hypocalcemia Induced by Denosumab

Author:

Okada Naoto1,Kawazoe Kazuyoshi12,Teraoka Kazuhiko1,Kujime Toshihide1,Abe Masahiro3,Shinohara Yasuo4,Minakuchi Kazuo12

Affiliation:

1. Department of Pharmacy, Tokushima University Hospital

2. Department of Clinical Pharmacy, Institute of Heath Biosciences, the University of Tokushima

3. Department of Medicine and Bioregulatory Sciences, Graduate School of Medical Sciences, University of Tokushima

4. Institute for Genome Research, University of Tokushima

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference21 articles.

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2. 2) Coleman RE. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin. Cancer Res., 12, 6243s–6249s (2006).

3. 3) Saad F, Gleason D, Murray R, Tchekmedyian S, Venner P, Lacombe L, Chin JL, Vinholes J, Goas J, Chen B, Group ZAPCS, Zoledronic Acid Prostate Cancer Study Group. A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma. J. Natl. Cancer Inst., 94, 1458–1468 (2002).

4. 4) Rosen LS, Gordon D, Tchekmedyian S, Yanagihara R, Hirsh V, Krzakowski M, Pawlicki M, de Souza P, Zheng M, Urbanowitz G, Reitsma D, Seaman J. Zoledronic Acid versus Placebo in the Treatment of Skeletal Metastases in Patients with Lung Cancer and Other Solid Tumors: A Phase III, Double-Blind, Randomized Trial—The Zoledronic Acid Lung Cancer and Other Solid Tumors Study Group. J. Clin. Oncol., 21, 3150–3157 (2003).

5. 5) Kohno N, Aogi K, Minami H, Nakamura S, Asaga T, Iino Y, Watanabe T, Goessl C, Ohashi Y, Takashima S. Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: a randomized, placebo-controlled trial. J. Clin. Oncol., 23, 3314–3321 (2005).

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