RecQ5 Protein Translocation into the Nucleus by a Nuclear Localization Signal

Author:

Sakurai Haruna1,Tsutsui Ayaka1,Higashi Takahiro1,Azuma Rika1,Ito Fumiaki1,Kawasaki Katsumi12

Affiliation:

1. Division of Biochemistry, Graduate School of Pharmaceutical Sciences, Setsunan University

2. Division of Molecular Biology, Department of Life Science, Faculty of Science and Engineering, Setsunan University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference30 articles.

1. 1) Ellis NA, Groden J, Ye TZ, Straughen J, Lennon DJ, Ciocci S, Proytcheva M, German J. The Bloom’s syndrome gene product is homologous to RecQ helicases. Cell, 83, 655–666 (1995).

2. 2) Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD. Positional cloning of the Werner’s syndrome gene. Science, 272, 258–262 (1996).

3. 3) Kitao S, Shimamoto A, Goto M, Miller RW, Smithson WA, Lindor NM, Furuichi Y. Mutations in RECQL4 cause a subset of cases of Rothmund–Thomson syndrome. Nat. Genet., 22, 82–84 (1999).

4. 4) Siitonen HA, Kopra O, Kääriäinen H, Haravuori H, Winter RM, Säämänen AM, Peltonen L, Kestilä M. Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases. Hum. Mol. Genet., 12, 2837–2844 (2003).

5. 5) Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G. RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev., 21, 3073–3084 (2007).

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