ent-Kaurane and ent-Pimarane Diterpenes from Siegesbeckia pubescens Inhibit Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglia

Author:

Lee Mina1,Kim Seung Hyun2,Lee Hee Kyoung3,Cho Yekyung1,Kang Jimmy1,Sung Sang Hyun1

Affiliation:

1. College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University

2. College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University

3. Institute for Life Science, Elcomscience Co., Ltd.

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference38 articles.

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2. 2) Gao HM, Hong JS. Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol., 29, 357–365 (2008).

3. 3) Aquilano K, Baldelli S, Rotilio G, Ciriolo MR. Role of nitric oxide synthases in Parkinson’s disease: a review on the antioxidant and anti-inflammatory activity of polyphenols. Neurochem. Res., 33, 2416–2426 (2008).

4. 4) Meng XL, Yang JY, Chen GL, Zhang LJ, Wang LH, Li J, Wang JM, Wu CF. RV09, a novel resveratrol analogue, inhibits NO and TNF-alpha production by LPS-activated microglia. Int. Immunopharmacol., 8, 1074–1082 (2008).

5. 5) Li A, Simmons PJ, Kaur P. Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. Proc. Natl. Acad. Sci. U.S.A., 95, 3902–3907 (1998).

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