Acute and Subacute Toxicity of the Extract of Aristolochiae Fructus and Honey-Fried Aristolochiae Fructus in Rodents

Author:

Yuan Jin-Bin1,Huang Qun1,Ren Gang1,Shi Min2,Chen Lai3,Yang Wu-Liang1,Chen Hai-Fang1,Yang Ming1,Yang Biao1,Yang Gai-Hong1,Luo Xiao-Quan3

Affiliation:

1. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine

2. College of Basic Medicine, Jiangxi University of Traditional Chinese Medicine

3. Laboratory Animal Center of Science and Technology, Jiangxi University of Traditional Chinese Medicine

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference31 articles.

1. 1) Chinese Pharmacopoeia Commission. Chinese Pharmacopoeia. 2010 ed., China Medical Science Press, Beijing, p. 49 (2010).

2. 2) Stiborová M, Frei E, Breuer A, Bieler CA, Schmeiser HH. Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with Chinese herbs nephropathy. Exp. Toxicol. Pathol., 51, 421–427 (1999).

3. 3) Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M. Richard C, Vandervelde D, Verbeelen D, Vanhaelen-Fastre R, Vanhaelen M. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet, 341, 387–391 (1993).

4. 4) Lemy A, Wissing KM, Rorive S, Zlotta A, Roumeguere T, Muniz MC, Decaestecker C, Salmon I, Abramowicz D, Vanherweghem JL, Nortier J. Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: a case series with 15-year follow-up. Am. J. Kidney Dis., 51, 471–477 (2008).

5. 5) Jelaković B, Karanovic S, Vukovic-Lela I, Miller F, Edwards KL, Nikolic J, Tomic K, Slade N, Brdar B, Turesky RJ, Stipancic Z, Dittrich D, Grollman AP, Dickman KG. Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid. Kidney Int., 81, 559–567 (2012).

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