Study of Umbelliferone Hydroxylation to Esculetin Catalyzed by Polyphenol Oxidase

Author:

Garcia-Molina Mary of the Sea1,Munoz-Munoz Joseph Louis1,Garcia-Molina Francis1,Rodriguez-Lopez Joseph Neptune1,Garcia-Canovas Francis1

Affiliation:

1. Investigation Group of Enzimology (GENZ), Department of Biochemistry and Molecular Biology A, University of Murcia, Campus of International Excellence “Campus Mare Nostrum”

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference34 articles.

1. 1) Sánchez-Ferrer A, Rodríguez-López JN, García-Cánovas F, García-Carmona F. Tyrosinase: a comprehensive review of its mechanism. Biochim. Biophys. Acta, 1247, 1–11 (1995).

2. 2) Rodríguez-López JN, Fenoll LG, Peñalver MJ, García-Ruiz PA, Varón R, Martínez-Ortíz F, García-Cánovas F, Tudela J. Tyrosinase action on monophenols: evidence for direct enzymatic release of o-diphenol. Biochim. Biophys. Acta, 1548, 238–256 (2001).

3. 3) Ros JR, Rodríguez-López JN, Varón R, García-Cánovas F. Kinetics study of the oxidation of 4-tert-butylphenol by tyrosinase. Eur. J. Biochem., 222, 449–452 (1994).

4. 4) Sollai F, Zucca P, Sanjust E, Steri D, Rescigno A. Umbelliferone and esculetin: inhibitors or substrates for polyphenol oxidases? Biol. Pharm. Bull., 31, 2187–2193 (2008).

5. 5) Bayoumi SA, Rowan MG, Beeching JR, Blagbrough IS. Investigation of biosynthetic pathways to hydroxycoumarins during post-harvest physiological deterioration in Cassava roots by using stable isotope labelling. ChemBioChem, 9, 3013–3022 (2008).

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