X-Ray Crystallographic Structure of RNase Po1 That Exhibits Anti-tumor Activity

Author:

Kobayashi Hiroko1,Katsutani Takuya2,Hara Yumiko2,Motoyoshi Naomi1,Itagaki Tadashi1,Akita Fusamichi2,Higashiura Akifumi2,Yamada Yusuke3,Inokuchi Norio1,Suzuki Mamoru2

Affiliation:

1. School of Pharmacy, Nihon University

2. Institute for Protein Research, Osaka University

3. Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference58 articles.

1. 1) Nomura H, Inokuchi N, Kobayashi H, Koyama T, Iwama M, Ohgi K, Irie M. Purification and primary structure of a new guanylic acid specific ribonuclease from Pleurotus ostreatus. J. Biochem., 116, 26–33 (1994).

2. 2) Yoshida H. The ribonuclease T1 family. Methods in Enzymology. (Nicolson AW ed.) Vol. 341, Academic Press, New York, pp. 28–41 (2001).

3. 3) Sugio S, Amisaki T, Ohishi H, Tomita K. Refined X-ray structure of the low pH form of ribonuclease T1-2′-guanylic acid complex at 1.9 Å resolution. J. Biochem., 103, 354–366 (1988).

4. 4) Nonaka T, Mitsui Y, Irie M, Nakamura KT. Three-dimensional structure of ribonuclease Ms 3′-guanylic acid complex at 2.5 Å resolution. FEBS Lett., 283, 207–209 (1991).

5. 5) Arni R, Heinemann U, Tokuoka R, Saenger W. Three-dimensional structure of the ribonuclease T1/2′-GMP complex at 1.9-A resolution. J. Biol. Chem., 263, 15358–15368 (1988).

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