Xanthocidin Derivatives as Topoisomerase IIα Enzymatic Inhibitors

Author:

Takeda Shuso1,Yaji Kentaro2,Matsumoto Kenji3,Amamoto Toshiaki4,Shindo Mitsuru3,Aramaki Hironori1

Affiliation:

1. Department of Molecular Biology, Daiichi University of Pharmacy

2. Interdisciplinary Graduate School of Engineering Sciences, Kyushu University

3. Institute for Materials Chemistry and Engineering, Kyushu University

4. NEUES Corporation

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference13 articles.

1. 1)  Asahi K, Nagatsu J, Suzuki S. Xanthocidin, a new antibiotic. J. Antibiot., 19, 195–199 (1966).

2. 2)  Yaji K, Shindo M. Total synthesis of (±)-xanthocidin using FeCl3-mediated Nazarov reaction. Tetrahedron, 66, 9808–9813 (2010).

3. 3)  Tius MA, Patterson GM, Astrab DP. Synthesis and in vitro activity of some methylenomycin analogs. J. Antibiot., 38, 1061–1067 (1985).

4. 4)  Takeda S, Matsuo K, Yaji K, Okajima-Miyazaki S, Harada M, Miyoshi H, Okamoto Y, Amamoto T, Shindo M, Omiecinski CJ, Aramaki H. (−)-Xanthatin selectively induces GADD45γ and stimulates caspase-independent cell death in human breast cancer MDA-MB-231 cells. Chem. Res. Toxicol., 24, 855–865 (2011).

5. 5)  Takeda S, Noguchi M, Matsuo K, Yamaguchi Y, Kudo T, Nishimura H, Okamoto Y, Amamoto T, Shindo M, Omiecinski CJ, Aramaki H. (−)-Xanthatin up-regulation of the GADD45γ tumor suppressor gene in MDA-MB-231 breast cancer cells: role of topoisomerase IIα inhibition and reactive oxygen species. Toxicology, 305, 1–9 (2013).

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