Alteration of Tumor Microenvironment for Improved Delivery and Intratumor Distribution of Nanocarriers

Author:

Ishida Tatsuhiro1,Kiwada Hiroshi1

Affiliation:

1. Department of Pharmacokinetics and Biopharmaceutics, Institute of Health Biosciences, The University of Tokushima

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference67 articles.

1. 1) Iyer AK, Khaled G, Fang J, Maeda H. Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov. Today, 11, 812–818 (2006).

2. 2) Gerlowski LE, Jain RK. Microvascular permeability of normal and neoplastic tissues. Microvasc. Res., 31, 288–305 (1986).

3. 3) Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl. Acad. Sci. U.S.A., 95, 4607–4612 (1998).

4. 4) Yuan F, Leunig M, Berk DA, Jain RK. Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. Microvasc. Res., 45, 269–289 (1993).

5. 5) Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res., 46, 6387–6392 (1986).

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