Anti-atrial Fibrillatory and Cardiorenal Protective Effects of the Combination of Valsartan and Cilnidipine in Dahl Salt-Sensitive Rats

Author:

Harada Eri12,Sugino Kazumi12,Takahara Akira3

Affiliation:

1. EA Pharma Co., Ltd. (Formerly Ajinomoto Pharmaceuticals Co., Ltd.)

2. Ajinomoto Co., Inc.

3. Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University

Publisher

Pharmaceutical Society of Japan

Reference26 articles.

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2. 2) Dzeshka MS, Shahid F, Shantsila A, Lip GYH. Hypertension and atrial fibrillation: an intimate association of epidemiology, pathophysiology, and outcomes. Am. J. Hypertens., 30, 733–755 (2017).

3. 3) Savelieva I, Kakouros N, Kourliouros A, Camm AJ. Upstream therapies for management of atrial fibrillation: review of clinical evidence and implications for European Society of Cardiology guidelines. Part I: primary prevention. Europace, 13, 308–328 (2011).

4. 4) Yamashita T, Inoue H, Okumura K, et al. Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM II study). Europace, 13, 473–479 (2011).

5. 5) Harada E, Sugino K, Aimoto M, Takahara A. Effects of the L/N-type Ca2+ channel blocker cilnidipine on the cardiac histological remodelling and inducibility of atrial fibrillation in high-salt-fed rats. Biol. Pharm. Bull., 44, 707–713 (2021).

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