Synthesis and Antinociceptive Activity of Orally Active Opioid Peptides: Improvement of Oral Bioavailability by Esterification
Author:
Affiliation:
1. Research Institute, Daiichi Fine Chemical Co., Ltd.
2. Department of Physiology and Anatomy, Tohoku Pharmaceutical University
Publisher
Pharmaceutical Society of Japan
Subject
Drug Discovery,General Chemistry,General Medicine
Link
http://www.jstage.jst.go.jp/article/cpb/51/7/51_7_759/_pdf
Reference35 articles.
1. 1) Symbols and abbreviations are in accordance with recommendations of IUPAC-IUB Joint Commission on Biochemical Nomenclature: Nomenclature and Symbolism for Amino Acids and Peptides. Biochem. J., 219, 345—373 (1984). The other abbreviations are as follows: AcOH, acetic acid; Ad, adamantyl; Bu, n-butyl; Bui, isobutyl; But, tert-butyl; Bzl, benzyl; Boc, tert-butyloxycarbonyl; cHex, cyclohexyl; Dec, decyl; Dde, dodecyl; DMF, N,N-dimethylformamide; EtOAc, ethyl acetate; Hde, hexadecyl; Hep, heptyl; Hex, hexyl; HOBt, 1-hydroxybenzotriazole; MeβAla, N-methyl-β-alanine; MetO, methionine (R,S)-sulfoxide; Non, nonyl; Oct, octyl; Pen, pentyl; Ph, phenyl; Pr, n-propyl; Pri, isopropyl; TEA, triethylamine; EDC·HCl, 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride.
2. Synthetic peptides related to the dermorphins. I. Synthesis and biological activities of the shorter homologues and of analogues of the heptapeptides
3. Structure-activity relationships of dermorphin synthetic analogues
4. The dermorphin peptide family
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