1. 1) Present address: Post Marketing Product Development, Astellas Pharma Inc.; 3–4–7 Doshomachi, Chuo-ku, Osaka 541–8514, Japan.
2. 2) Present address: Drug Metabolism Research Laboratories, Astellas Pharma Inc.; 1–1–8 Azusawa, Itabashi-ku, Tokyo 174–8511, Japan.
3. 3) Present address: Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc.; 2–1–6 Kashima, Yodogawa-ku, Osaka 532–8514, Japan.
4. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes