Interindividual Variability in 5-Fluorouracil Metabolism and Procainamide N-Acetylation in Human Liver Cytosol

Author:

Niwa Toshiro12,Shiraga Toshifumi1,Ohno Yasuo3,Kagayama Akira1

Affiliation:

1. Biopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

2. Post-marketing Development Research Center, Fujisawa Pharmaceutical Co., Ltd.

3. Division of Pharmacology, Biological Safety Research Center, National Institute of Health Sciences, Japan

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference27 articles.

1. 1) Present address: Post Marketing Product Development, Astellas Pharma Inc.; 3–4–7 Doshomachi, Chuo-ku, Osaka 541–8514, Japan.

2. 2) Present address: Drug Metabolism Research Laboratories, Astellas Pharma Inc.; 1–1–8 Azusawa, Itabashi-ku, Tokyo 174–8511, Japan.

3. 3) Present address: Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc.; 2–1–6 Kashima, Yodogawa-ku, Osaka 532–8514, Japan.

4. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

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