Biological Significance of Isoaspartate and Its Repair System

Author:

Shimizu Takahiko1,Matsuoka Yasuji2,Shirasawa Takuji1

Affiliation:

1. Research Team for Molecular Biomarkers, Tokyo Metropolitan Institute of Gerontology

2. Center for Dementia Research, Nathan Kline Institute for Psychiatric Research and Department of Psychiatry, New York University School of Medicine

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference86 articles.

1. 1) Present address: Department of Neurology, Georgetown University Medical Center, 4000 Reservoir Rd. N.W., Washington, DC 20057, U.S.A.

2. Age-dependent deamidation of asparagine residues in proteins

3. Aging as war between chemical and biochemical processes: Protein methylation and the recognition of age-damaged proteins for repair

4. Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

5. 5) Brennan T. V., Clarke S., “Deamidation and Isoaspatate Fomation in Peptides and Proteins,” ed. by Aswad D. W., CRC Press, Boca Raton, 1995, pp. 65—90.

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