Dexamethasone Suppresses Neurosteroid Biosynthesis via Downregulation of Steroidogenic Enzyme Gene Expression in Human Glioma GI-1 Cells

Author:

Koibuchi Fuyuko1,Ritoh Natsumi1,Aoyagi Ryohei1,Funakoshi-Tago Megumi1,Tamura Hiroomi1

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Keio University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference38 articles.

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3. 3) Kerr DS, Campbell LW, Thibault O, Landfield PW. Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging. Proc. Natl. Acad. Sci. U.S.A., 89, 8527–8531 (1992).

4. 4) Yau JL, Seckl JR. Local amplification of glucocorticoids in the aging brain and impaired spatial memory. Front. Aging Neurosci., 4, 1–15 (2012).

5. 5) de Kloet CS, Vermetten E, Geuze E, Kavelaars A, Heijnen CJ, Westenberg HG. Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. J. Psychiatr. Res., 40, 550–556 (2006).

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