Effect of Short-term Polyphenol Treatment on Endothelial Dysfunction and Thromboxane A2 Levels in Streptozotocin-Induced Diabetic Mice

Author:

Taguchi Kumiko1,Hida Mari1,Matsumoto Takayuki1,Ikeuchi-Takahashi Yuri2,Onishi Hiraku2,Kobayashi Tsuneo1

Affiliation:

1. Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University

2. Department of Drug Delivery Research, Hoshi University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference38 articles.

1. 1) Hadas K, Randriamboavonjy V, Elgheznawy A, Mann A, Fleming I. Methylglyoxal induces platelet hyperaggregation and reduces thrombus stability by activating PKC and inhibiting PI3K/Akt pathway. PLoS ONE, 8, e74401 (2013).

2. 2) Matsumoto T, Watanabe S, Kawamura R, Taguchi K, Kobayashi T. Enhanced uridine adenosine tetraphosphate-induced contraction in renal artery from type 2 diabetic Goto–Kakizaki rats due to activated cyclooxygenase/thromboxane receptor axis. Pflugers Arch., 466, 331–342 (2014).

3. 3) Mellor DD, Madden LA, Smith KA, Kilpatrick ES, Atkin SL. High-polyphenol chocolate reduces endothelial dysfunction and oxidative stress during acute transient hyperglycaemia in type 2 diabetes: a pilot randomized controlled trial. Diabet. Med., 30, 478–483 (2013).

4. 4) Raz I, Wilson PW, Strojek K, Kowalska I, Bozikov V, Gitt AK, Jermendy G, Campaigne BN, Kerr L, Milicevic Z, Jacober SJ. Effects of prandial versus fasting glycemia on cardiovascular outcomes in type 2 diabetes: the HEART2D trial. Diabetes Care, 32, 381–386 (2009).

5. 5) de Jager J, Dekker JM, Kooy A, Kostense PJ, Nijpels G, Heine RJ, Bouter LM, Stehouwer CD. Endothelial dysfunction and low-grade inflammation explain much of the excess cardiovascular mortality in individuals with type 2 diabetes: the Hoorn Study. Arterioscler. Thromb. Vasc. Biol., 26, 1086–1093 (2006).

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