Insight into the Mechanism of Reproductive Dysfunction Caused by Neonicotinoid Pesticides

Author:

Hoshi Nobuhiko1,Hirano Tetsushi1,Omotehara Takuya1,Tokumoto Junko1,Umemura Yuria1,Mantani Youhei2,Tanida Takashi3,Warita Katsuhiko4,Tabuchi Yoshiaki5,Yokoyama Toshifumi1,Kitagawa Hiroshi2

Affiliation:

1. Laboratory of Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University

2. Laboratory of Histophysiology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University

3. Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine

4. Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University

5. Division of Molecular Genetics Research, 
Life Science Research Center, University of Toyama

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference12 articles.

1. 1) Warita K, Okamoto K, Mutoh K, Hasegawa Y, Yue Z-P, Yokoyama T, Matsumoto Y, Miki T, Takeuchi Y, Kitagawa H, Sugawara T, Hoshi N. Activin A and equine chorionic gonadotropin recover reproductive dysfunction induced by neonatal exposure to an estrogenic endocrine disruptor in adult male mice. Biol. Reprod., 78, 59–67 (2008).

2. 2) Maeda N, Okumura K, Tanaka E, Suzuki T, Miyasho T, Haeno S, Ueda H, Hoshi N, Yokota H. Downregulation of cytochrome P450scc as an initial adverse effect of adult exposure to diethylstilbestrol on testicular steroidogenesis. Environ. Toxicol. (2013). [Epub ahead of print] doi: 10.1002/tox.21875.

3. 3) Warita K, Mitsuhashi T, Sugawara T, Tabuchi Y, Tanida T, Wang ZY, Matsumoto Y, Yokoyama T, Kitagawa H, Miki T, Takeuchi Y, Hoshi N. Direct effects of diethylstilbestrol on the gene expression of the cholesterol side-chain cleavage enzyme (P450scc) in testicular Leydig cells. Life Sci., 87, 281–285 (2010).

4. 4) Warita K, Mitsuhashi T, Fukui S, Ohta K, Suzuki S, Miki T, Takeuchi Y, Yokoyama T, Kitagawa H, Sugawara T, Hoshi N. Immunohistochemical analysis of steroidogenic acute regulatory protein (StAR) and StAR-binding protein (SBP) expressions in the testes of mice during fetal development. Reprod. Biol., 13, 92–95 (2013).

5. 5) Warita K, Mitsuhashi T, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y. In vitro evaluation of gene expression changes for gonadotropin-releasing hormone 1, brain-derived neurotrophic factor, and neurotrophic tyrosine kinase, receptor, type 2, in response to bisphenol A treatment. Congenit. Anom. (Kyoto), 53, 42–45 (2013).

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