Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor-Reference-Cited by-同舟云学术

Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor

Published:2018 Issue:3 Volume:66 Page:243-250
ISSN:0009-2363
Container-title:Chemical and Pharmaceutical Bulletin
language:en
Short-container-title:CHEMICAL & PHARMACEUTICAL BULLETIN

Author:

Kadoh Yoichi¹,Miyoshi Haruko¹,Matsumura Takehiko¹,Tanaka Yoshihito¹,Hongu Mitsuya¹,Kimura Mayumi¹,Takedomi Kei¹,Omori Kenji¹²,Kotera Jun¹,Sasaki Takashi¹,Kobayashi Tamaki¹,Taniguchi Hiroyuki¹,Watanabe Yumi¹,Kojima Koki¹,Sakamoto Toshiaki¹,Himiyama Toshiyuki¹,Kawanishi Eiji¹

Affiliation:

1. Mitsubishi Tanabe Pharma Corporation

2. Industry and Academia Cooperation Research Project, Laboratory of Target and Drug Discovery, Graduate School of Pharmaceutical Sciences, Nagoya University

Publisher

Pharmaceutical Society of Japan

Subject

Drug Discovery,General Chemistry,General Medicine

Link

https://www.jstage.jst.go.jp/article/cpb/66/3/66_c17-00783/_pdf

Reference23 articles.

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3. 3) Kotera J., Fujishige K., Yuasa K., Omori K., Biochem. Biophys. Res. Commun., 261, 551–557 (1999).

4. 4) Fujishige K., Kotera J., Omori K., Eur. J. Biochem., 266, 1118–1127 (1999).

5. 5) Kotera J., Sasaki T., Kobayashi T., Fujishige K., Yamashita Y., Omori K., J. Biol. Chem., 279, 4366–4375 (2004).

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