DISORDER OF INNATE IMMUNITY AND THE SEVERITY OF IMMUNOCOMPLEX REACTIONS IN PREGNANT WOMEN WITH MISCARRIAGE AGAINST THE BACKGROUND OF EXTRAGENITAL PATHOLOGY

Abstract

The functional activity of monocytes and the concentration of circulating immune complexes in the blood of pregnant women with chronic liver disease and early reproductive losses were studied. In pregnant women in the first trimester of gestation with an unfavorable premorbid background, a decrease in the phagocytic activity of monocytes was revealed, which indicates a decrease in the functional ability of the macrophages of the future mother. Along with the lack of nonspecific resistance of the body, the examined patients showed an increase in circulating immune complexes due to pathogenic medium-molecular fractions. The lowest indicators of monocyte phagocytic activity and a significant increase in the concentration of circulating immune complexes were found in patients with exacerbation of non-alcoholic steatohepatitis, which could provoke premature termination of pregnancy in the first trimester.