HYDRAZIDE OF o-HYDROXYBENZOIC ACID AND ITS DERIVATIVES. SYNTHESIS AND PROPERTIES-Reference-Cited by-同舟云学术

HYDRAZIDE OF o-HYDROXYBENZOIC ACID AND ITS DERIVATIVES. SYNTHESIS AND PROPERTIES

Published:2020-02-15 Issue:383 Volume:1 Page:14-25
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Author:

О. А. Nurkenov ¹^ORCID,S. D. Fazylov ²^ORCID,M. Zh. Zhurinov ³^ORCID,Zh. B. Satpaeva ⁴^ORCID,М. Zh. Burkeev ⁵^ORCID,T. M. Seilkhanov ⁶^ORCID,E. D. Satybaldin ⁷^ORCID

Affiliation:

1. Doctor of chemical sciences, Professor, Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan; nurkenov_oral@mail.ru; https://orcid.org/0000-0003-1878-2787

2. Corresponding member of NAS RK, Doctor of chemical sciences, Professor, Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan; iosu8990@mail.ru;

3. Academician of NAS RK, Doctor of Chemical Sciences, Professor, Institute of Fuel, Elec-trochemistry and Catalysis named after D.V.Sokolskiy; nanrk.mzh@mail.ru; https://orcid.org/0000-0001-5314-1219

4. Doctoral student of Buketov Karaganda State University; satpaeva_zh@mail.ru; https://publons.com/researcher/P-4887-2017/; https://orcid.org/0000-0003-0962-1148

5. Acting Dean of the Faculty of Chemistry of Buketov Karaganda State University; https://publons.com/researcher/2339931/meyram-z-burkeev/; m_burkeev@mail.ru; https://orcid.org/0000-0001-8084-4825

6. Candidate of Chemical Sciences, Sh. Ualikhanov Kokshetau State University; tseilkhanov@mail.ru; https://orcid.org/0000-0003-0079-4755

7. master Karaganda State Technical University MES RK; catybaldin_e@mail.ru; https://orcid.org/0000-0003-0662-3658

Abstract

The article presents the results of a study by the authors of the article on the development of new ways of synthesis and study of the biological activity of hydrazide derivatives of o-hydroxybenzoic acid. Methods for the preparation of hydrazone, oxadiazole, thiosemicarbazide, 1,2,4-triazole-3-thionic derivatives and methods for their further modification are described. The condensation reaction of hydroxybenzoic acid hydrazides with 1-deoxy-2,3,4,6-tetra-O-acetyl-D-glucopyranosyl isothiocyanate synthesized their corresponding acetylated glycosyl-contai-ning thiosemicarbazide derivatives. The structures of the synthesized compounds were studied by 1H and 13C NMR spectroscopy, as well as by the data of two-dimensional spectra of COSY (1H-1H) and HMQC (1H-13C). The values of chemical shifts, multiplicity, and integrated intensity of 1H and 13C signals in one-dimensional NMR spectra were determined. Using spectra in the formats COSY (1Н-1Н) and HMQC (1Н-13С), homo- and heteronuclear interactions were established, confirming the structure of the compounds under study. The results of evaluating their antimicrobial, anti-inflammatory and cytotoxic activity (in vitro) on cultures of human monocytic cell lines MonoMac-6 and THP-1Blue are described.

Publisher

National Academy of Sciences of the Republic of Kazakshtan

Link

http://www.bulletin-science.kz/images/pdf/v20201/14-25.pdf

Reference34 articles.

1. Lisina SV, Brel AK, Mazanova LS, Spasov AA (2008) Synthesis and antipyretic activity of new derivatives of salicylic acid [Sintez i zharoponizhayushchaya aktivnost' novykh proizvodnykh salitsilovoy kisloty] 10:24-26 (in Russ.).

2. Belikov VG (1993) Synthetic and natural medicines [Sinteticheskiye i prirodnyye lekarstvennyye sredstva] Higher School, Moscow. ISBN: 5060029859 (in Russ.).

3. Mashkovsky MD (2012) Medicines [Lekarstvennyye sredstva] RIA New Wave LLC, Moscow. ISBN: 5786402878 (in Russ.).

4. Mashkovsky MD (1998) Medications of the 20th century [Lekarstva XX veka] New Wave LLC, Moscow. ISBN: 5-7864-0072-7 (in Russ.).

5. Belikov VG (1985) Pharmaceutical Chemistry [Farmatsevticheskaya khimiya] Higher School, Moscow. ISBN: 5-06-003253-1 (in Russ.).