ANTIULCER, ANALGESIC AND HEPATOPROTECTIVE ACTIVITIES OF HYDROALCOHOLIC ROOT EXTRACT OF JURINEA DOLOMIAEA BOISS

Abstract

The herb Jurinea Dolomiaea Boiss, which is a member of the Astraceae family, has long been used in Ayurveda to treat liver diseases and as an anticancer, antioxidant, and anti-diabetic. The antiulcer, analgesic, and hepatoprotective effects of Jurinea dolomiaea Boiss aqueous and hydroalcoholic root extracts against carbon tetrachloride-induced hepatotoxicity in albino wistar rats were investigated in this work. The experimental rats were given Jurinea dolomiaea root hydroalcoholic extract (100 mg/kg and 200 mg/kg p.o.) daily for seven days. By measuring SGOT, SGPT, ALP, and total bilirubin, the hydroalcoholic extract of Jurinea dolomiaea roots was examined for its hepatoprotective properties. The toxic effect of carbon tetrachloride was greatly reduced in the rats treated with the hydroalcoholic extract of Jurinea dolomiaea roots by restoring the elevated levels of SGOT, SGPT, ALP, and total bilirubin compared to the toxicant control. Jurinea dolomiaea root hydroalcoholic extract shown notable hepatoprotective effects.