“A comparative study of Nebivolol plus Amlodipine and Atenolol plus Amlodipine on blood pressure and heart rate in patients of essential hypertensive patients”

Abstract

Objectives: Study was conducted to compare the evaluation of efficacy and safety of Nebivolol plus Amlodipine combination with Atenolol plus Amlodipine combination in hypertensive patients.Materials and Methods: A Prospective Observational study was conducted at tertiary care teaching hospital which included a total 334 patients with essential hypertension. The demographic and baseline data, Blood pressure and Heart rate of the patients were recorded. After baseline investigation patients were randomly divide into 2 groups. All patients were subsequently monitored and reassessed at 4th-week, 8th week and 12th weeks of interval during each follow-up.Results: Nebivolol plus Amlodipine group include a total 169 patients in which 129 patients were males and 40 patients were females with mean age 46.89 ±12.48 years, Atenolol plus Amlodipine group include a total 165 patients in which 111patients were males and 54 patients were females with mean age 48.19±12.14 years. Patients were receiving Nebivolol plus Amlodipine and Atenolol plus Amlodipine showed a significant fall in systolic blood pressure (SBP), Diastolic blood pressure (DBP) and Heart rate at the end of 4th, 8th and 12th weeks of interval as compared to their baseline data.Conclusion: A Study revels that Reduction of blood pressure and Heart rate were similar in both treatment groups (Nebivolol plus Amlodipine and Atenolol plus Amlodipine).(P- value >0.05)