A REVIEW: MICROEMULSION-BASED POLYMER MATRIX TRANSDERMAL PATCH FOR THE TREATMENT OF INFLAMMATION

Abstract

The inflammation is the Immunogenic response when a foreign particle or material or any antigen is entered in the body. The topical delivery or a transdermal delivery is defined as it is a route of administration of a drug via skin or to protect the drug from the metabolism process. The topical formulations are of different types such as lotion, creams, patches, gels and ointments. The transdermal patches are the system where the medicine is diffused from the matrix of polymer and penetrates the skin and the drug shows the therapeutic benefit to the patient. Microemulsion patches are the novel delivery system in which the drug is in micron size ranges and then easily penetrates the skin and becomes a more successful drug delivery over the conventional patches. The microemulsions are the thermodynamically stable biphasic seen as a clear solution in which the drug is entrapped in a dispersed phase and the continuous phase is work as the vehicle for the administration of the dose. There are some tests like entrapment efficiency and Invitro drug release testing for determination of its efficacy. There are some characterization tests like electro conductivity study, rheological properties and centrifugation study has also performed the folding endurance surface pH and the water content and the stability testing has been performed. The microemulsion patch drug delivery system has been found to have more bioavailability and duration of action than the conventional patches or the topical formulation.