Anticancer properties of nanoparticle synthesized from Cyphostemma auriculatum. Roxb on nude mice

Abstract

The present study was aimed to establish the pharmacological and therapeutic properties of a green synthesized silver nanoparticles (AgNPs) in breast cancer induced by 7,12-dimethylbenzanthracene (DMBA) in nude mice. In this study, AgNPs made from Cyphostemma auriculatum Roxb. leaf extract( CA-AgNPs) were tested in a nude mice model for anticancer activity. A significant elevate changes in blood chemistry like heamoglobin, RBC, WBC,  platelets and also on blood biochemical parameters such as catalase and SOD with obtained after 28 days of treatment with carcinogen. However, these levels were restored to normal at the end of the study period treated with CA-AgNPs. The liver oxidative stress enzymes showed no significant alterations. With 15 and 30 mg/kg b.w of CA-AgNP, histopathological analysis revealed no significant abnormalities in the kidney, spleen, lungs, heart, testis, or brain. However, 30 mg/kg b.w. of CA-AgNPs caused considerable cell edema and vacuolar degeneration in the liver, which returned to normal at the conclusion of the washout period. The findings of this study suggest that green produced CA-AgNPs at low concentrations could be beneficial.