The antimicrobial effect of silver nanoparticles coated with silica against human pathogenic bacteria and fungi

Abstract

The antibacterial property of silver (Ag) has been known since ancient time. It is reported in the literature that silver nanoparticles (AgNPs) exhibit improved antibacterial and antifungal properties in comparison to silver ions of equivalent metallic Ag concentration.A simple method has been used based on solenoid soles for the synthesis of nanoparticles of silver coated on silica. AgNPs were compared positively with silver nitrate solution and ampicillin standard antibiotics at a concentration of 50μg / mL (Table 1 and 2). AgNPs mentioned in the silica activity exhibited more than standard silver nitrate and antibiotics. AgNPs were fairly toxic to Salmonella sp., Neisseria sp., Klebsiella sp., and Pseudomonas sp. with an inhibition zone 21, 24, 16, 23 mm respectively. AgNPs exhibited strong antifungal activity against fungal strains (Candida sp., Aspergillus fumigatus and Aspergillus flavus) in different concentrations such as 30-50 and 60 μg/ml were examined for antifungal activity. AgNPs revealed the highest antifungal activity with the inhibition zone 26, 25 and 22 mm respectively. Results of the present study prevealed that AgNPs have a remarkable potential as antimicrobial agent in treating infectious diseases.