Physiological and histological studies of dental response of Luxate tooth with application of VEGF

Abstract

Background During luxate injury many dental tissue will be involved including pulp, periodontal ligament ,mucosa, hard dental tissue and alveolar bone with affecting the nerve and dental blood supplement. Growth factors may involved in healing process after replantation of tooth in its socket and the  Vascular endothelial factor (VEGF )  is a potent one that increase angiogenesis and accelerate repairing  and healing of dental pulp and the supporting tissues. The study was designed to illustrate the effect of application of growth factor on healing process of luxate molar tooth of rat. Materials & Methods Twenty male Wistar rats with luxate lower right first molar teeth were included in this study. The control were injected  with normal saline (0.5μl ) around the apex of mesial root .Experimental  group injected with  VEGF (0.5μl ). Histological assessment of  physiological responses of (dental pulp, cementum, periodontal ligament (PDL) and alveolar bone in both control and experimental groups with Receptor activator of nuclear factor kappa-Β ligand (RANKL) expression  evaluation were recorded during the healing period in the examined tissue.