Author:
Thakur Nishant,Kaur Bhupinder,Sharma Chandan,Goswami Manish
Abstract
The skin irritation and sensitization potential of the new transdermal patch of the Thiocolchicoside formulated with Dura 87-6908 was evaluated on the rabbits and guinea pig as per the standard guidelines of OECD. Skin irritation test was performed on the rabbits by applying the placebo patch for 72 hours and dermal reactions like edema, erythema were noted. No clinical signs or dermal reactions were observed in the rabbits. Sensitization potential was measure on the guinea pig and animal was challenged to transdermal therapeutic system of the Thiocolchicoside, negative control group while group exposed to CDNB produced the sensitization reactions. These findings proved that Thiocolchicoside does not produce any dermal toxicity, irritation and sensitization and hence it is safe for dermal use.
Publisher
Universidad Tecnica de Manabi
Subject
Education,General Nursing
Reference19 articles.
1. M. Carta et al., “The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system,” Neuropharmacology, 2006, doi: 10.1016/j.neuropharm.2006.05.023.
2. J. R. T. Patil P.H., Patil P.R., “Formulation and Evaluation of Semisolid preparation (Ointment, Gel & Cream) of Thiocolchicoside,” J. Pharm. Biomed. Sci., 2011.
3. R. K. Nanda, S. S. Patil, and D. A. Navathar, “Chiotsan nanoparticles loaded with thiocolchicoside,” Der Pharma Chem., 2012.
4. G. C. Ceschel et al., “In vitro permeation screening of a new formulation of thiocolchicoside containing various enhancers,” Drug Deliv. J. Deliv. Target. Ther. Agents, vol. 9, no. 4, pp. 259–263, 2002, doi: 10.1080/10717540260397882.
5. Z. Abbas and S. SACHIN, “Indian Journal of Novel Drug Delivery,” Indian J. Nov. Drug Deliv., vol. 4, no. 1, pp. 2–16, 2012.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献