Mucin expression in liver tumors

Abstract

Difficulties in diagnosis, the prevalence of oncological processes, their medical, social and economic significance and high mortality rate determine the relevance of the fight against them and make the problem of studying the mechanisms of their early diagnosis one of the key ones. The subject of research now is the description of many biological markers, the determination of which allows us to assess the risks of developing a disease, diagnose a tumor, and serve as a biological indicator of the tumor process. The subjects of the study were tissue samples from 65 patients with liver cancer. The level of antibodies to MUC-1 and MUC-13 was studied. The established value of the concentration of antibodies to MUC-1 and MUC-13 in the blood serum of people with liver cancer is higher than the values in practically healthy individuals (p = 0.002; p = 0.0001), and the concentration of antibodies to MUC-1 and MUC-13 in the tissue tumors of cancer patients is higher than in the blood serum of healthy individuals and patients with liver cancer (p<0.05). The expression level of MUC-1 and MUC-13 in the tumor tissue is not related to the age and sex of patients.