Evaluation of antimicrobial activity of ellagic acid on Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Escherichia coli

Abstract

Serious infections, and rising resistant infections, by pathogenic bacteria, have become developing threats worldwide. There is an increasing need to develop and discover a new treatment options that can act effectively to cure infections, with lesser resistance, side effects and toxicity. Identification of new treatment options against pathogens is an important issue nowadays. Ellagic acid is a non-drug compound that has been shown to possess many biological activities and  is presented in many red fruits and berries. This study aims to evaluate and measure the antimicrobial activity and the minimum bactericidal concentration (MBC) of ellagic acid on Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Escherichia coli. The antibacterial activity of ellagic acid was evaluated against ten purified bacterial isolates via agar disc diffusion assay, and minimum bactericidal concentration assay (MBC). The results show that ellagic acid was an effective antimicrobial compound against all the tested pathogens. The MBC range was shown to be between (1-2) mg/ml for MRSA, and E.coli, and between(1-1.5) mg/ml for P. aeruginosa. This current study has detected and proved the antimicrobial activity of ellagic acid against important and widely resistant pathogenic bacteria like MRSA, P.  aeruginosa, and E.coli.