Pyrazole as an anti-inflammatory scaffold

Abstract

Inflammation is a common component behind pathophysiology of many chronic diseases like cardiovascular, arthritis, bowel disorders, cancer, chronic wounds, and lesions which are the most significant cause of death in the world, according to the World Health Organization. Chronic inflammation associated diseases are expected to increase persistently by the next 30 years as 3 of 5 people die daily due to chronic inflammatory diseases. So, the prerequisite of novel anti-inflammatory agents has been noteworthy increased than ever. Heterocyclic compounds are being developed at the large pace over the most recent couple of decades due to their intriguing pharmacological activities. The most remarkable and well-known heterocyclic nucleus is pyrazole which has pulled the consideration of numerous specialists to explore its wide potential. Pyrazole derivatives are considered as valuable class of compounds owing to their extremely noticeable anti-inflammatory activity. This review delivers a vast summary of pyrazole derivatives developed last decade for their action against inflammation along with docking studies with a hope that it will be useful for medicinal chemists working in anti-inflammatory drug development.