Author:
Manjunath P. N,Seth A. K.,Anand K. R,Satish C. S
Abstract
Ramelteon is an orally sleep promoting agent that is chemically designated as (S)- N- [2-(1,6,7,8-Tetrahydro-2H-indeno-[5,4b] furan-8-yl) ethyl] propionamide and contains one chiral centre. Ramelteon is a neutral compound with no acid or base functional groups, and as such, its aqueous solubility is independent of pH. The activity of Ramelteon at the MT1and MT2 receptors is believed to contribute to its sleep-promoting properties, as these receptors, acted upon by endogenous melatonin, are thought to be involved in the maintenance of the circadian rhythm underlying the normal sleep-wake cycle. These maintenance of circadian rhythm can be well controlled by designing the formulations with chronotherapeutic drug delivery system. This article summarizes to design, develop and evaluate the chronotherapeutic drug delivery system with various approaches using control release polymers like Eudragit RSPO, Hydroxy propyl methyl cellulose (HPMC), Ethyl cellulose etc., the approaches like compression coating technique, pulsatile drug delivery system and coating technique. The main objective of controlling the drug release pattern is to achieve the lag time of 2 hours followed by drug release profile for 4 hours. Also an attempt has been made to conclude on various approaches studied which can be used in the treatment of circadian rhythm using Ramelteon API.
Publisher
Universidad Tecnica de Manabi
Subject
Education,General Nursing
Reference29 articles.
1. Manjunath. P.N. etal., Approaches on chronotherapeutic drug delivery system and its impact on circadian rhythm. International Journal of pharmaceutical research. Apr- Jun 2021; Volume 13 issue 2.
2. Jharna Bansal. Circadian Cycle and Chronotherapy: Role in the Treatment of Various Biological Disorders. World Applied Sciences Journal 32 (5): 825-838, 2014.ISSN 1818-4952.
3. Annabelle Ballesta, Pasquale F. Innominato, Robert Dallmann, David A. Rand and Francis A. Lévi Stephanie W. Watts. Systems Chronotherapeutics. Pharmacological Reviews, 2017; 69 (2) 161-199.
4. R. Santosh Kumar., G.V. Radha, K. Lakshmi Deepthi and P. Sujitha. An update on chronotherapeutic drug delivery systems. Indo American journal of pharmaceutical research, 2015; Vol 5, Issue 09:2857.
5. Fukui E, Uemura K, Kobayashi M. Studies on applicability of press-coated tablets using hydroxypropylcellulose (HPC) in the outer shell for timed-release preparations. J Control Release. 2000 Aug 10;68(2):215-23.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献