Fifteenth Century Saints, Nineteenth Century Neurologists, and Twentieth Century Immunotherapy: The Eccentric History of Multiple Sclerosis

Abstract

Multiple sclerosis has a long, fascinating, serendipi- tous, and well-documented history. The first recorded mention of the disease can be dated back to the fifteenth century, while a truly exhaustive investigation of the disorder began with the nineteenth century’s burgeoning neurologists. These records reveal a fascinating story of meticulous science aimed at comprehending a truly perplexing illness, one that even today is not completely understood. The great nineteenth century French neurologist Jean-Marie Charcot became very interested in studying this disease, and through his celebrity garnered much attention to a previously unknown affliction. Here we review a story of pioneering research that grants brief tribute to some of the more remarkable experiments, wondering if ideas born in the past may help develop solutions in the future.